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UNC10013

CAT: 0804-HY-173156-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-173156-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC10013 is a SETDB1 allosteric modulator that forms a covalent bond with Cys385 in the 3TD domain, exhibiting negative allosteric regulatory activity. It has a kinact/KI value of 1.0 x 106 M-1*s-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation and holds potential value for research in cancer and neurodegenerative diseases.
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer; Neurological Disease
Smiles
O=C(NC1=CC2=C(NCCCCCCN(C)C)N=C(NCCCCCN(C)C)N=C2C=C1)/C=C/CN(C)C.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Molecular Formula
C37H54F12N8O9
Molecular Weight
982.85
References & Citations
[1]Uguen M, et al. Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells. Nat Commun. 2025 Feb 24;16 (1) :1905.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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