RegisterLogin

UNC10088

CAT: 0804-HY-178321Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178321Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
UNC10088 is a molecular glue targeting NSD2. UNC10088 mediates the formation of a stable ternary complex between SCFFBXO22 and the NSD2 PWWP1 domain. UNC10088 promotes ubiquitination of the SCFFBXO22-dependent NSD2 PWWP1 domain through reversible covalent bonding with the C326 region of FBXO22. UNC10088 could be used in cancer research[1].
UNSPSC
12352005
Target
Histone Methyltransferase; Molecular Glues
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
OC(CCCCC(N1CCC2=CC(NC(C3=CC=C(C=C3)CN(C4CC4)C(C5=CC6=C(NC(CO6)=O)C=C5)=O)=O)=CC=C2C1)=O)S(=O)(O[Na])=O
Molecular Formula
C35H37N4NaO9S
Molecular Weight
712.74
References & Citations
[1]Robertson KC, et al. Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22. bioRxiv [Preprint]. 2025 Aug 30:2025.08.29.673087.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-173156-01UNC10013
HY-179241UNC10062

Alternative Products

CatalogName

Popular Products