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SLW131

CAT: 0804-HY-173052Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173052Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SLW131 (Compound 10) is the antagonist for CCR7 with a good affinity of Ki of 9.85 nM. SLW131 inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM, inhibits β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 inhibits CCL19-induced cell morphological changes in primary BMDCs, and CCR7-mediated migration in mouse CD4+ T cell[1].
CAS Number
681511-84-2
UNSPSC
12352005
Target
CXCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=CC(NC(C(N[C@H](C(C)(C)C)C2=CC=C(O2)C)=N3)=NS3(=O)=O)=C1O)N(C)C
Molecular Formula
C21H27N5O5S
Molecular Weight
461.53
References & Citations
[1]Wurnig SL, et al., A Fluorescent Probe Enables the Discovery of Improved Antagonists Targeting the Intracellular Allosteric Site of the Chemokine Receptor CCR7. J Med Chem. 2025 Feb 27;68 (4) :4308-4333.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T205065-01SLW131

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