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SLW131

CAT: 0013-GTR19249600-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249600-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SLW131 (Compound 10) is a potent and selective CCR7 antagonist with a Ki of 9.85 nM. It effectively inhibits CCL19-induced G protein signaling (IC50 = 29.4 μM) and β-arrestin2 recruitment (IC50 = 6.0 μM), suppressing dendritic cell morphological changes and T-cell migration in vitro. This tool compound is useful for studying CCR7-mediated immune cell trafficking in research contexts.
CAS Number
681511-84-2
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Smiles
N ([C@H] ([C@@] (C) (C) C) C=1OC (C) =CC1) C=2C (NC3=C (O) C (C (N (C) C) =O) =CC=C3) =NS (=O) (=O) N2
Molecular Formula
C21H27N5O5S
Molecular Weight
461.535
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-173052SLW131

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