YTHDF2-IN-1

CAT: 0804-HY-173008-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-173008-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YTHDF2-IN-1 (Compound CK-75) is the inhibitor for YT521-B homology domain family 2 YTHDF2 (Kd=26.2 μM), that blocks the interaction between YTHDF2 and m6A RNA. YTHDF2-IN-1 inhibits the colony formation of JAR cells, exhibits antiproliferative activity in a variety of cancer cells (IC50 in micromolar levels), arrests the cell cycle at G0/G1 phase, induces apoptosis in K562[1].
UNSPSC
12352005
Target
Apoptosis; YTHDF
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.42
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(N2N=CC(C(C3=C4C=CC=CC4=CC=C3O)=O)=C2)C=C1
Molecular Formula
C21H14N2O4
Molecular Weight
358.35
References & Citations
[1]Qiu X, et al., Phenylpyrazoles as Inhibitors of the m6A RNA-Binding Protein YTHDF2. JACS Au. 2025 Feb 10;5 (2) :618-630.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YTHDF2

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