YTHDF2-IN-1

• Description :

  YTHDF2-IN-1 (Compound CK-75) is the inhibitor for YT521-B homology domain family 2 YTHDF2 (Kd=26.2 μM), that blocks the interaction between YTHDF2 and m6A RNA. YTHDF2-IN-1 inhibits the colony formation of JAR cells, exhibits antiproliferative activity in a variety of cancer cells (IC50 in micromolar levels), arrests the cell cycle at G0/G1 phase, induces apoptosis in K562[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; YTHDF

• Related Pathways :

  Apoptosis; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  99.42

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C1=CC=C(N2N=CC(C(C3=C4C=CC=CC4=CC=C3O)=O)=C2)C=C1

• Molecular Formula :

  C21H14N2O4

• Molecular Weight :

  358.35

• References & Citations :

  [1]Qiu X, et al., Phenylpyrazoles as Inhibitors of the m6A RNA-Binding Protein YTHDF2. JACS Au. 2025 Feb 10;5 (2) :618-630.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  YTHDF2