YTHDC1-IN-1

• Description:

  YTHDC1-IN-1 is a selective YTHDC1 inhibitor with a Kd of 49 nM and an IC50 of 0.35 μM. YTHDC1-IN-1 can inhibit the proliferation and induce apoptosis of acute myeloid leukemia cell lines. YTHDC1-IN-1 has anti-tumor activity[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; DNA/RNA Synthesis; PARP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ythdc1-in-1.html

• Purity:

  99.44

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CNC1=NC(Cl)=NC2=C(CC3=CC=CC(Cl)=C3)NN=C21

• Molecular Formula:

  C13H11Cl2N5

• Molecular Weight:

  308.17

• References & Citations:

  [1]František Zálešák, et al. Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J Med Chem. 2024 Jun 13;67 (11) :9516-9535.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2995344-53-9]