YTHDC1-IN-1

CAT: 0804-HY-158974-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-158974-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YTHDC1-IN-1 is a selective YTHDC1 inhibitor with a Kd of 49 nM and an IC50 of 0.35 μM. YTHDC1-IN-1 can inhibit the proliferation and induce apoptosis of acute myeloid leukemia cell lines. YTHDC1-IN-1 has anti-tumor activity[1].
CAS Number
[2995344-53-9]
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ythdc1-in-1.html
Purity
99.44
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CNC1=NC(Cl)=NC2=C(CC3=CC=CC(Cl)=C3)NN=C21
Molecular Formula
C13H11Cl2N5
Molecular Weight
308.17
References & Citations
[1]František Zálešák, et al. Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J Med Chem. 2024 Jun 13;67 (11) :9516-9535.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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