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ACLY-IN-1

CAT: 0804-HY-172914Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172914Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity (IC50 = 8.3 nM) and high binding affinity (KD = 72.0 nM) to ACLY. ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect[1].
CAS Number
2897695-26-8
UNSPSC
12352101
Target
ATP Citrate Lyase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cardiovascular Disease; Metabolic Disease
Smiles
ClC1=CC2=CC(S(=O)(NC3=CC(C4=C(C=CC(Br)=C4)CNC2=O)=C(C=C3F)F)=O)=C1O
Molecular Formula
C20H12BrClF2N2O4S
Molecular Weight
529.74
References & Citations
[1]Zang Y, et.al., Design, synthesis, and Biological evaluation of novel macrocyclic derivatives as potent ATP-citrate lyase inhibitors. Eur J Med Chem. 2025 Aug 5;292:117684.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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