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Anti-inflammatory agent 102

CAT: 0804-HY-172871Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172871Size:1 Each
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Description
Anti-inflammatory agent 102 (Compound 11a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 102 exerts its anti-inflammatory effect by blocking the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. Anti-inflammatory agent 102 has significant anti-inflammatory activity and can inhibit the release of NO, ROS, and inflammatory factors (such as IL-6, TNF-α, IL-1β) . Anti-inflammatory agent 102 can be used in the study of inflammatory diseases such as ulcerative colitis (UC) [1].
CAS Number
3053104-47-2
UNSPSC
12352005
Target
Interleukin Related; MAP3K; NF-κB; NO Synthase; p38 MAPK; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Smiles
COC1=C(N2CCN(C3=CC=CC=N3)C2=O)C=C(Cl)C(OC)=C1
Molecular Formula
C16H16ClN3O3
Molecular Weight
333.77
References & Citations
[1]Juan Zhang, et al. Discovery of novel N- (5-chloro-2,4-dimethoxyphenyl) -N-heterocyclic ketone analogs as potent anti-inflammatory agents against ulcerative colitis. Bioorganic Chemistry, Volume 161, 2025, 108576, ISSN 0045-2068.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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