CDC20-IN-2

CAT: 0804-HY-172401Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172401Size:1 Each
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Description
CDC20-IN-2 (14c), a Cdc20 inhibitor (KD: 7.65 μM), causes G2/M phase arrest and promotes DNA damage accumulation. CDC20-IN-2 (14c) stabilizes key substrates such as Cyclin B1 and Bim, leading to enhanced apoptosis and suppression of tumor cell proliferation and migration[1].
CAS Number
[3080812-16-1]
UNSPSC
12352005
Target
APC; Apoptosis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC(F)(F)C1=CC=C(NC2=CC(Cl)=NC(NC(NC(OCCNC(C3=CN=C(C(F)(F)F)S3)=O)=O)C(Cl)(Cl)Cl)=N2)C=C1
Molecular Formula
C21H15Cl4F6N7O3S
Molecular Weight
701.26
References & Citations
[1]Xiangyang Le, et al. Design, synthesis and optimization of Apcin analogues as Cdc20 inhibitors for triple-negative breast cancer therapy. Eur J Med Chem. 2025 May 5:289:117434.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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