Thalidomide-NH-C4-Boc

• Description:

  Thalidomide-NH-C4-Boc is the conjugate composed of an E3 ligase (Cereblon) ligand and a linker that can be used for synthesis of PROTAC CARM1/IKZF3 degrader-1 (HY-172368) [1].

• UNSPSC:

  12352005

• Target:

  E3 Ligase Ligand-Linker Conjugates

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Smiles:

  O=C1N(C2C(NC(CC2)=O)=O)C(C3=C(NCCCCCC(OC(C)(C)C)=O)C=CC=C31)=O

• Molecular Formula:

  C23H29N3O6

• Molecular Weight:

  443.49

• References & Citations:

  [1]Ni W, et al. Dual CARM1-and IKZF3-targeting: a novel approach to multiple myeloma therapy Synergy between CARM1 inhibition and IMiDs[J]. Molecular Therapy Oncology, 2025.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2226139-38-2]