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Thalidomide-NH-C10-Boc

CAT: 0804-HY-161961Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161961Size:1 Each
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Description
Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which can recruit Cereblon ubiquitinase. Thalidomide-NH-C10-Boc can couple the target protein ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, Thalidomide-NH-C10-Boc can couple with the ligand EP300/CBP ligand 2 to produce the PROTAC molecule dCE-2 (HY-161958).
CAS Number
2428400-25-1
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-nh-c10-boc.html
Smiles
O=C(N1C2CCC(NC2=O)=O)C3=CC=CC(NCCCCCCCCCCC(OC(C)(C)C)=O)=C3C1=O
Molecular Formula
C28H39N3O6
Molecular Weight
513.63
References & Citations
[1]Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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