WEHI-3773

• Description:

  WEHI-3773 is an inhibitor of the interaction between VDAC2 and BAK or BAX. WEHI-3773 inhibits BAX-mediated Apoptosis by blocking the VDAC2-mediated recruitment of BAX to mitochondria. Conversely, WEHI-3773 promotes BAK-mediated Apoptosis by limiting the inhibitory sequestration of BAK by VDAC2. WEHI-3773 is promising for research in the field of anti-cancer [1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Bcl-2 Family

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  99.89

• Smiles:

  CSC1=CC=C (N2C (/C (C3=C (N) C (C#N) =C (N) N=C32) =C4C (N (C5=CC=C (SC) C=C5) C6=NC (N) =C (C#N) C (N) =C6/4) =O) =O) C=C1

• Molecular Formula:

  C30H22N10O2S2

• Molecular Weight:

  618.69

• References & Citations:

  [1]Li K, et al. Differential regulation of BAX and BAK apoptotic activity revealed by small molecules. Sci Adv. 2025 Mar 7;11 (10) :eadr8146.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported