WEHI-150

CAT: 0931-MF-0038449-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0038449-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
70492-21-6
Target
DNA Alkylator/Crosslinker|||Others
Related Pathways
DNA Damage/DNA Repair|||Others
Bioactivity
WEHI-150 is an analog of mitoxantrone, a DNA interstrand cross-linker (t1/2=12.5 h) . WEHI-150 is capable of forming covalent adducts on CpG sequences, with a particular preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand cross-linking and blocks transcription in a concentration-dependent manner. WEHI-150 mediates the formation of covalent adducts that do not interact with guanine N-2 and forms adducts on new DNA sequences.
Smiles
N(CCNCCN)C1=C2C(=C(NCCNCCN)C=C1)C(=O)C=3C(C2=O)=C(O)C=CC3O
Molecular Formula
C22H30N6O4
Molecular Weight
442.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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