WEHI-150

• Target:

  DNA Alkylator/Crosslinker|||Others

• Related Pathways:

  DNA Damage/DNA Repair|||Others

• Bioactivity:

  WEHI-150 is an analog of mitoxantrone, a DNA interstrand cross-linker (t1/2=12.5 h) . WEHI-150 is capable of forming covalent adducts on CpG sequences, with a particular preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand cross-linking and blocks transcription in a concentration-dependent manner. WEHI-150 mediates the formation of covalent adducts that do not interact with guanine N-2 and forms adducts on new DNA sequences.

• Smiles:

  N(CCNCCN)C1=C2C(=C(NCCNCCN)C=C1)C(=O)C=3C(C2=O)=C(O)C=CC3O

• Molecular Formula:

  C22H30N6O4

• Molecular Weight:

  442.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  70492-21-6