ES9-17

• Description:

  ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC) . ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H312, H332

• Target:

  Clathrin; Dynamin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/es9-17.html

• Concentration:

  10mM

• Purity:

  99.87

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=CC=C(Br)S1)(NC2=CC=CC=C2)=O

• Molecular Formula:

  C10H8BrNO2S2

• Molecular Weight:

  318.21

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Dejonghe W, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15 (6) :641-649. |[2]Huang L, et al. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. Curr Opin Plant Biol. 2019 Dec;52:106-113.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [55854-43-8]