ES9-17

• Description :

  ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC) . ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings[1][2].

• CAS Number :

  [55854-43-8]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332

• Target :

  Clathrin; Dynamin

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/es9-17.html

• Concentration :

  10mM

• Purity :

  99.87

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=S(C1=CC=C(Br)S1)(NC2=CC=CC=C2)=O

• Molecular Formula :

  C10H8BrNO2S2

• Molecular Weight :

  318.21

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Dejonghe W, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15 (6) :641-649. |[2]Huang L, et al. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. Curr Opin Plant Biol. 2019 Dec;52:106-113.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported