BCP-NC2-C12

• Description:

  BCP-NC2-C12 is an ionizable cationic lipid. BCP-NC2-C12 can be used to generate lipid nanoparticles (LNPs) for in vivo delivery of mRNA. BCP-NC2-C12 LNPs mediated an approximately 90% reduction in PCSK9 serum protein levels via CRISPR/Cas9 gene knockout[1].

• UNSPSC:

  12352211

• Target:

  Liposome

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Smiles:

  O=C(C12CC(C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(C2)C1)NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC

• Molecular Formula:

  C59H116N4O2

• Molecular Weight:

  913.58

• References & Citations:

  [1]Wu S, et al. Isosteric 3D Bicyclo[1.1.1]Pentane (BCP) Core-Based Lipids for mRNA Delivery and CRISPR/Cas Gene Editing. J Am Chem Soc. 2024 Dec 18;146 (50) :34733-34742.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported