C12-Ceramide

• Description :

  C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].

• Product Name Alternative :

  N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine

• UNSPSC :

  12352211

• Hazard Statement :

  H225, H319

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/c12-ceramide.html

• Purity :

  99.82

• Solubility :

  DMSO : 2.5 mg/mL (ultrasonic)

• Smiles :

  CCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O

• Molecular Formula :

  C30H59NO3

• Molecular Weight :

  481.79

• Precautions :

  H225, H319

• References & Citations :

  [1]He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314 (1) :116-20.|[2]Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8 (44) :76921-76934.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [74713-60-3]