C12-Ceramide

CAT: 0804-HY-100353-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100353-01Size:5 mg
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Description
C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].
CAS Number
[74713-60-3]
Product Name Alternative
N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/c12-ceramide.html
Purity
99.82
Solubility
DMSO : 2.5 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
Molecular Formula
C30H59NO3
Molecular Weight
481.79
Precautions
H225, H319
References & Citations
[1]He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314 (1) :116-20.|[2]Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8 (44) :76921-76934.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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