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DAurAB5

CAT: 0804-HY-171770-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171770-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DAurAB5 is a dual Aurora-A (DC50 = 8.8 nM) and Aurora-B (DC50 = 6.1 nM) PROTAC degrader. dAurAB5 induces degradation of Aurora-A and Aurora-B, reduces N-Myc levels, and decreases viability in IMR32 neuroblastoma cells. dAurAB5 downregulates the levels of AAK1, PTK2, GAK, and TTK. dAurAB5 can be used to study cancers such as neuroblastoma. (Pink: TTK ligand 2: HY-168542, Blue: Thalidomide-O-COOH: HY-103597, Black: 6-Aminocaproic acid: HY-B0236).
UNSPSC
12352005
Target
AAK1; Aurora Kinase; Cyclin G-associated Kinase (GAK) ; FAK; Mps1; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Neuronal Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
99.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCCCCC(N1CCN(C2=CC=C(NC3=NC(NC4CCCCC4)=C5N=CNC5=N3)C=C2)CC1)=O)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O
Molecular Formula
C42H49N11O7
Molecular Weight
819.91
References & Citations
[1]Nelson SE, et al. Development of Dual Aurora-A and Aurora-B Degrading PROTACs for MCYN-Amplified Neuroblastoma. ChemMedChem. 2025 Mar 3;20 (5) :e202400703.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B; Cereblon

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