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DAurAB5

CAT: 0931-T212449-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212449-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
AAK1 (AP2 associated kinase 1), PROTACs, Kinesin, Aurora Kinase, Serine/threonin kinase, FAK
Related Pathways
Cytoskeletal Signaling, PROTAC, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Neuroscience, Metabolism, Cell Cycle/Checkpoint, Angiogenesis
Bioactivity
DAurAB5 is a dual PROTAC degrader targeting Aurora-A (DC50= 8.8 nM) and Aurora-B (DC50= 6.1 nM) . It induces the degradation of Aurora-A and Aurora-B, leading to reduced N-Myc levels and decreased viability of IMR32 neuroblastoma cells. Additionally, dAurAB5 downregulates the levels of AAK1, PTK2, GAK, and TTK. This compound is applicable in cancer research, including neuroblastoma.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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