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Anticonvulsant agent 9

CAT: 0804-HY-170930Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170930Size:1 Each
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Description
Anticonvulsant agent 9 (compound 4f) is an α1β2γ2 GABAA receptors activator. Anticonvulsant agent 9 activatesα1β2γ2 GABAA receptors with an EC50 of 1.24 μM. Anticonvulsant agent 9 inhibits the inactivation of Nav1.2 channels. Anticonvulsant agent 9 exhibits significant anticonvulsant activities[1].
UNSPSC
12352005
Target
GABA Receptor; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
COC1=CC=C(C2=NN3C(N(CCCC)C(CC3C4=CC=CC=C4)=O)=N2)C=C1
Molecular Formula
C22H24N4O2
Molecular Weight
376.45
References & Citations
[1]Du T, et al. Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABAA1 and Nav1.2 with antiepileptic activity. Eur J Med Chem. 2025 Mar 15;286:117316.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.2

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