Products for Research Use Only
RegisterLogin

KIT/PDGFRA-IN-1

CAT: 0804-HY-170911Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-170911Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
KIT/PDGFRA-IN-1 (compound 19) is a stem cell growth factor receptor (KIT) and platelet-derived growth factor receptor alpha (PDGFRA) inhibitor. KIT/PDGFRA-IN-1 inhibits KIT-wt, KIT-D816H, KIT-T670I, PDGFRA-wt, PDGFRA-D842V, PDGFRA-T674I and PDGFRA-G680R with IC50s of 2.3, 12, 492, 0.8, 99.9, 42.3, and 4.3 μM, respectively. KIT/PDGFRA-IN-1 inhibits GIST-T1, T1-a-D842V and GIST-48B cells (PDGFR- and KIT-Mutant GIST cell Lines) with GR50s of 12, 8900, ≥10 000 nM, respectively[1].
UNSPSC
12352005
Target
PDGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=C(C=C(C=C1)C(NC2=CC(C(F)(F)F)=C(C=C2)NC(C=C)=O)=O)C#CC3=CN=C4N3N=CC=C4
Molecular Formula
C26H18F3N5O2
Molecular Weight
489.45
References & Citations
[1]Schulz T, et al. Design, Synthesis, and SAR of Covalent KIT and PDGFRA Inhibitors-Exploring Their Potential in Targeting GIST. J Med Chem. 2025 Feb 13;68 (3) :3238-3259.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-175212PDGFRA-IN-1
HY-149510MET/PDGFRA-IN-1
HY-173124CDK2/FLT4/PDGFRA-IN-1
HY-149511MET/PDGFRA-IN-2
HY-174549Human PDGFRA mRNA
HY-RS10256PDGFRA Rat Pre-designed siRNA Set A
HY-RS10254PDGFRA Human Pre-designed siRNA Set A
HY-RS10255Pdgfra Mouse Pre-designed siRNA Set A
HY-144653-01PDGFR-IN-1
HY-169520VEGFR/PDGFR-IN-1

Alternative Products

CatalogName
GTR19249036-01KIT/PDGFRA-IN-1
T211658-01PDGFRA-IN-1
GTR19230878-01MET/PDGFRA-IN-1
cyt-065-01PDGFRA
T206827-01CDK2/FLT4/PDGFRA-IN-1
GTR19272854-01PDGFRA/CAIX/XII-IN-1
E029674Human PDGFRa ELISA Kit
E043517Mouse PDGFRa ELISA Kit
OKCD07965-96WPDGFRA ELISA Kit (Human)
OKEH07103-96WPDGFRA ELISA Kit (Rat)

Popular Products