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JAK-IN-39

CAT: 0804-HY-170723Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170723Size:1 Each
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Description
JAK-IN-39 (compound 11) is a JAK inhibitor that suppresses JAK1, JAK2, JAK3 with IC50 values of 0.05, 1.18, and 0.03 nM, respectively. JAK-IN-39 can inhibit the viability of TF-1 cells and also suppress the production of lymphocyte TNFα and INFγ in vitro[1].
CAS Number
2250013-34-2
UNSPSC
12352005
Target
JAK; TNF Receptor
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Smiles
COC1=NC(C2=NN3C(N[C@H]4C(C)(CN(C5=CC=C(N=N5)C#N)CC4)C)=C(C(N)=O)C=NC3=C2)=CC=C1
Molecular Formula
C25H26N10O2
Molecular Weight
498.54
References & Citations
[1]Michal MROCZKIEWICZ, et al. Pyrazole[1,5-a]pyrimidine derivatives as kinase jak inhibitors.WO. WO2018206739A1. 2018-05-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK2; JAK3

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