YB-3–17

• Description:

  YB-3-17 is a bifunctional molecule, that inhibits mTOR (IC50=0.22 nM) or degrades G1 to S phase transition 1 gene (GSPT1, DC50=5 nM) in a PROTAC mechanism. YB-3-17 exhibits antiproliferative activity in multi glioblastoma cell lines with IC50 of nanomolare levels. YB-3-17 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-170407) ; Black: linker (HY-A0102) ; Blue: ligand for E3 ligase Cereblon (HY-14658) )

• UNSPSC:

  12352005

• Target:

  MTOR; PROTACs

• Related Pathways:

  PI3K/Akt/mTOR; PROTAC

• Field of Research:

  Cancer

• Smiles:

  NC(O1)=NC2=C1C=CC(C3=NN(C4CCN(C(C5CCC(CNC6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)=O)CC4)C9=NC=NC(N)=C93)=C2

• Molecular Formula:

  C38H39N11O6

• Molecular Weight:

  745.79

• References & Citations:

  [1]Liu Y, et al., A Dual-Target and Dual-Mechanism Design Strategy by Combining Inhibition and Degradation Together. J Am Chem Soc. 2024 Dec 2.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2940242-88-4]