C-Kit-IN-9

• Description:

  Kit-IN-9 (Compound D9) is an inhibitor of c-Kit. c-Kit-IN-9 inhibits the inflammatory responses in J774A.1, RAW264.7, MPMs cells and lung tissues by blocking the activation of the NF-κB pathway induced by LPS (HY-D1056) . Meanwhile, c-Kit-IN-9 exhibits good anti-inflammatory activities in acute lung injury and sepsis mouse models. c-Kit-IN-9 can be used in the research of acute lung injury and related inflammatory diseases[1].

• UNSPSC:

  12352005

• Target:

  C-Kit

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(C1=CC(OC2=CC=C(C=C2)NC(C3=CN(C4=C(C3=O)C=CC=C4)C5=CC=C(C=C5)F)=O)=CC=N1)NCCC6=CC=CS6

• Molecular Formula:

  C34H25FN4O4S

• Molecular Weight:

  604.65

• References & Citations:

  [1]Luo W, et al. Discovery of c-Kit as a New Therapeutic Target in LPS-Induced Acute Lung Injury through Novel Phenylamide Derivative D9. J Med Chem. 2025 Apr 10;68 (7) :7499-7517.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported