TAK-756

• Description:

  TAK-756 is a TAK1 inhibitor with good selectivity for IRAK1/4 and excellent intra-articular pharmacokinetic properties. TAK1 is a potential molecular target for osteoarthritis (OA) with complementary anti-catabolic and anti-inflammatory effects[1].

• UNSPSC:

  12352005

• Target:

  MAP3K

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(C1=CC(C2=NOC(C3=CC(CN4C)=C(C=C3O[C@@H]5CC[C@@H](CC5)O)C4=O)=C2)=CC=C1)N

• Molecular Formula:

  C25H25N3O5

• Molecular Weight:

  447.48

• References & Citations:

  [1]Langlois JB, et al. Identification of TAK-756, A Potent TAK1 Inhibitor for the Treatment of Osteoarthritis through Intra-Articular Administration. J Med Chem. 2024 Dec 12;67 (23) :21163-21185.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported