DDO-6079

• Description :

  DDO-6079 is a potent CDC37 inhibitor. DDO-6079 inhibits HSP90-CDC37 and CDC37-CDK4/6 chaperone complex by binding to an allosteric site on CDC37. DDO-6079 decreases the thermostability of CDK6[1].

• CAS Number :

  [2648334-53-4]

• UNSPSC :

  12352005

• Target :

  CDK

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Concentration :

  10mM

• Purity :

  98.92

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC(Cl)=CC=C1O)NC2=CC(OC3=CC=CC=C3)=NC=C2

• Molecular Formula :

  C18H13ClN2O3

• Molecular Weight :

  340.76

• References & Citations :

  [1]Zhang L, et al. Allosteric CDC37 Inhibitor Disrupts Chaperone Complex to Block CDK4/6 Maturation. Angew Chem Int Ed Engl. 2024 Nov 24:e202413618.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDC