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KRO-105714

CAT: 0804-HY-169864Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169864Size:1 Each
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Description
KRO-105714 is the antagonist for sphingosine phosphocholine receptor (SPC Receptor) and sphingosine-1-phosphate receptor 1 (S1P1 Receptor) (IC50=79.2 nM) . KRO-105714 inhibits SPC-induced proliferation of NIH3T3 (IC50=5.6 nM), inhibits SPC-induced cell migration (IC50=0.59 μM) and tube formation in HUVECs. KRO-105714 inhibits SPC-induced generation of IL-4 and IL-5, exhibits anti-inflammtory efficacy in mouse atopic dermatitis models[1].
CAS Number
1137536-21-0
UNSPSC
12352005
Target
LPL Receptor
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=C(NC(C(C)(C)C)=O)N=C(N2CCN(CC2)C3=C(OC)C=CC=C3)S1)C4=CC=CC=C4
Molecular Formula
C26H30N4O3S
Molecular Weight
478.61
References & Citations
[1]Yoon SB, et al., A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis. J Inflamm (Lond) . 2020 May 29;17:20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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