M351-0056

• Description:

  M351-0056 is the agonist for the immune checkpoint protein VISTA, that reduces the secretion of VISTA-induced cytokines, promotes the T-cell proliferation induced by VISTA, and exhibits immunomodulatory activity. M351-0056 ameliorates Imiquimod (HY-B0180) -induced psoriatic dermatitis in mouse models[1].

• UNSPSC:

  12352005

• Target:

  VISTA

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.48

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=S(NC1=CC=C(C=C1F)Br)(C2=C(C)SC(C3=CSC(C)=N3)=C2)=O

• Molecular Formula:

  C15H12BrFN2O2S3

• Molecular Weight:

  447.37

• References & Citations:

  [1]Hu X, et al., M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA. Br J Pharmacol. 2021 Mar;178 (6) :1445-1458.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1189495-81-5]