NA-17

• Target:

  MDM-2/p53|||Apoptosis

• Related Pathways:

  Apoptosis

• Bioactivity:

  NA-17 is a naphthalimide compound with antitumor activity and exhibits lower toxicity to normal cells such as HL-7702 and WI-38. It demonstrates p53-dependent inhibition selectivity in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of these cells. NA-17 causes cell cycle arrest in the G1 phase and promotes apoptosis and cell death.

• Smiles:

  O=C1C2=CC=CC=3C(=CC=C(C(=O)N1CCC4=CC=C5OCOC5=C4)C23)NCCCN(C)C

• Molecular Formula:

  C26H27N3O4

• Molecular Weight:

  445.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1708948-28-0