Products for Research Use Only
RegisterLogin

Yck2-IN-1

CAT: 0804-HY-168998Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-168998Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes) . In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection[1].
CAS Number
401816-26-0
UNSPSC
12352101
Target
Casein Kinase; Fungal
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Stem Cell/Wnt
Field of Research
Infection
Smiles
N#CC1=CN2N=C(C(C3=CC=NC=C3)=C2C=C1)C4=CC=C(C=C4)F
Molecular Formula
C19H11FN4
Molecular Weight
314.32
References & Citations
[1]Puumala E, et al. Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nat Commun. 2025 Mar 4;16 (1) :2156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N6838-011,1,1,1-Kestohexaose
HY-157129AMPK-α1β1γ1 activator 1
HY-1336231,1,1-Tribromoacetone
HY-149536TWIK-1/TREK-1-IN-1
HY-W160628S1,1,1-Trimethoxypropane-d5
HY-133630-011-Bromo-1,1-dichloroacetone
HY-W881439-011- (1,1-Dimethylethyl) tridecanedioate
HY-W032015S11-Bromooctane-1,1-d2
HY-1336291,1,1,3-Tetrachloroacetone
HY-112773-011,1′,1′′,1′′′-[1,4-Piperazinediylbis (2,1-ethanediylnitrilo) ]tetrakis[2-dodecanol]

Alternative Products

CatalogName
T206070-01Yck2-IN-1
GTR18010539YCK2 Antibody
MBS1255391Recombinant Saccharomyces cerevisiae Casein kinase I homolog 2 (YCK2) , partial
MBS7153834Rabbit anti-Saccharomyces cerevisiae (strain 204508/S288c)(Baker's yeast) YCK2 Polyclonal Antibody
OF59775-011,1,1,1,1-Kestoheptaose
N2864-5.11,1,1,1-Kestohexaose
1120401,1,1,1-Kestohexose
410417-011,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride
IFA69273-011-Iodobicyclo[1.1.1]pentane
OR3123881-Phenylbicyclo[1.1.1]pentane

Popular Products