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SHP1 activator 1

CAT: 0804-HY-168929-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-168929-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1 (SHP1) with an EC50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent[1].
UNSPSC
12352211
Target
Apoptosis; Fluorescent Dye; Phosphatase; SHP1; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.38
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1OC2=CC(N(CC)CC)=CC=C2C=C1C(NC3=CC=C(C(NCCN(CC)CC)=O)C=C3)=O
Molecular Formula
C27H34N4O4
Molecular Weight
478.58
References & Citations
[1]Mu XY, et al., Development of coumarin and procaine linked hybrid molecules as a novel class of SHP1 fluorescent activators. Eur J Med Chem. 2025 Apr 15;288:117394.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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