SHP1 activator 1

• Description:

  SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1 (SHP1) with an EC50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent[1].

• UNSPSC:

  12352211

• Target:

  Apoptosis; Fluorescent Dye; Phosphatase; SHP1; STAT

• Related Pathways:

  Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Purity:

  99.38

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C1OC2=CC (N (CC) CC) =CC=C2C=C1C (NC3=CC=C (C (NCCN (CC) CC) =O) C=C3) =O

• Molecular Formula:

  C27H34N4O4

• Molecular Weight:

  478.58

• References & Citations:

  [1]Mu XY, et al., Development of coumarin and procaine linked hybrid molecules as a novel class of SHP1 fluorescent activators. Eur J Med Chem. 2025 Apr 15;288:117394.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature, keep dry and cool

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported