LC3B recruiter 2

CAT: 0804-HY-168892-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-168892-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LC3B recruiter 2 (34R) is an LC3B recruiter and a component of the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), which directly binds to LC3B. LC3B recruiter 2 binds to CDK9 inhibitor SNS-032 (HY-10008) through a linker, forming an ATTEC that targets the degradation of the CDK9 and Cyclin T1 complex (with inhibitory effects on both) . Therefore, LC3B recruiter 2 exerts activity through the LC3B-dependent autophagy-lysosome pathway, interfering with the cell cycle of cancer cells, thus exhibiting antitumor activity[1].
CAS Number
[380636-64-6]
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Atg8/LC3; Autophagy
Related Pathways
Autophagy
Field of Research
Cancer
Purity
98.11
Solubility
DMSO : 35 mg/mL (ultrasonic)
Smiles
CCN1C(NC2=CC(Cl)=CC=C2C1=O)=O
Molecular Formula
C10H9ClN2O2
Molecular Weight
224.64
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zeng Y, et al. Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations. Eur J Med Chem. 2025 Apr 5;287:117293.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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