RET ligand-2

• Description :

  RET ligand-2 is a selective RET inhibitor. RET ligand-2 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC RET degraders with antitumor activity. RET ligand-2 can be used for the synthesis of RD-23 (HY-168867) [1].

• UNSPSC :

  12352005

• Target :

  Ligands for Target Protein for PROTAC; RET

• Related Pathways :

  PROTAC; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  COC1=NC=C(C=C1)CN2C3CC2CN(C3)C4=NC=C(C=C4)C5=CC(N6CC=C(CC6)N7CCNCC7)=CN8N=CC(C#N)=C58

• Molecular Formula :

  C34H38N10O

• Molecular Weight :

  602.73

• References & Citations :

  [1]Hualong M, et al. Discovery of a Selective and Orally Bioavailable RET Degrader with Effectiveness in Various Mutations. J Med Chem. 2025 Jan 7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3053537-08-6]