Aurora-A ligand 1

• Description :

  Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439) . HLB-0532259 shows anti-tumor activity against neuroblastoma[1].

• CAS Number :

  [2541626-73-5]

• UNSPSC :

  12352005

• Target :

  Aurora Kinase; Ligands for Target Protein for PROTAC

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics; PROTAC

• Field of Research :

  Cancer

• Concentration :

  10mM

• Purity :

  98.75

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N(C)C)C(N1C2CCCC2)=CC3=C1N=C(NC4=CC=C(C(O)=O)C=C4)N=C3

• Molecular Formula :

  C21H23N5O3

• Molecular Weight :

  393.44

• References & Citations :

  [1]Tang J, et al. Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem Biol. 2025 Jan 6:S2451-9456 (24) 00516-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported