Aurora-A Antibody

CAT: 0800-F50015-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F50015-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Auroria kinase A may play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. It may be involved in microtubule formation and/or stabilization. This protein has also been postulated to play a key role during tumor development and progression. Aurora kinase A localizes on centrosomes in interphase cells and at each spindle pole in mitosis. It is highly expressed in testis, weakly in skeletal muscle, thymus and spleen, and also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly afterward. Defects in Aurora kinase A are responsible for numerical centrosome aberrations including aneuploidy.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:10-1:50, Flow Cytometry: 1:10-1:50
UniProt
O14965
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 364-392 from the human protein was used as the immunogen for this Aurora-A antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, FACS, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Aurora-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Aurora-A antibody is available for research use only.
Storage Conditions
Aliquot the Aurora-A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Aurora-A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, nuclear
Image Legend
Western blot analysis of Aurora-A antibody and 293 cell lysate either nontransfected (Lane 1) or transiently transfected with the Aurora-A gene (2) . Predicted molecular weight ~45 kDa.

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