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Decarbamoylmitomycin C

CAT: 0804-HY-167635Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-167635Size:1 Each
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Description
Decarbamoylmitomycin C, an analog of Mitomycin C (MC), is an DNA-alkylating agent. Decarbamoylmitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction[1].
CAS Number
26909-37-5
UNSPSC
12352005
Target
ATM/ATR; Drug Derivative; MDM-2/p53
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CO[C@]12N(C[C@@]3([H])[C@]2([H])N3)C4=C(C(C(N)=C(C4=O)C)=O)[C@H]1CO
Molecular Formula
C14H17N3O4
Molecular Weight
291.30
References & Citations
[1]Maggie Zheng, et al. Synthesis of Mitomycin C and decarbamoylmitomycin C N6 deoxyadenosine-adducts. Bioorg Chem. 2019 Nov:92:103280.|[2]Gu Xiao, et al. Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction. Cell Cycle. 2015;14 (5) :744-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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