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(S) -LY-41

CAT: 0804-HY-165624ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-165624ASize:1 Each
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Description
(S) -LY-41, R-enantiomer of LY-41 , is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (S) -LY-41 is a potent and selective 5-HT1A receptor agonist. (S) -LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (S) -LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (S) -LY-41 can induce the 5-HT behavioral syndrome. (S) -LY-41can be used for the research of neurological disease, such as depression and anxiety[1].
CAS Number
136296-40-7
UNSPSC
12352005
Target
5-HT Receptor; Drug Derivative; Drug Isomer
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
CC(C1=CC=CC2=C1C[C@@H](N(CCC)CCC)CC2)=O
Molecular Formula
C18H27NO
Molecular Weight
273.41
References & Citations
[1]Yu H, et al. (R) - and (S) -8-acetyl-2- (dipropylamino) tetralin (LY-41) : two novel 5-HT1A receptor agonists. Eur J Pharmacol. 1993 Jan 26;231 (1) :69-76.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor