Phenformin (Standard)

• Description:

  Phenformin (Standard) is the analytical standard of Phenformin. This product is intended for research and analytical applications. Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].

• UNSPSC:

  12352100

• Target:

  AMPK; Apoptosis; Mitochondrial Metabolism; Reference Standards

• Related Pathways:

  Apoptosis; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR

• Field of Research:

  Cancer; Metabolic Disease

• Smiles:

  NC(NC(NCCC1=CC=CC=C1)=N)=N

• Molecular Formula:

  C10H15N5

• Molecular Weight:

  205.26

• References & Citations:

  [1]García Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20 (13) :3316.|[2]Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81 (4) :390-401.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [114-86-3]