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FAP6-19

CAT: 0804-HY-159771Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159771Size:1 Each
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Description
FAP6-19 is a fibroblast activation protein (FAP) targeting radioligand with a Kd of 18.2 nM. FAP6-19 selectively delivers therapeutic radioactive nuclides (such as 177Lu) to the tumor site by targeting the overexpressed FAP protein in the tumor microenvironment, achieving precise killing of cancer cells while minimizing radiation damage to healthy tissues. FAP6-19 exhibits extremely high total cellular uptake and good intracellular retention ability in HT1080 cells. After being labeled with 111In, FAP6-19 produced extremely high tumor/kidney and tumor/liver dose ratios in the mouse model with 4T1 tumors. FAP6-19 can be used in the research of solid tumors expressing FAP.
CAS Number
3095069-75-0
UNSPSC
12352209
Target
FAP
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NCCCC[C@H](NC(C1=CC=C(CNC(CCCC2=CC=C(I)C=C2)=O)C=C1)=O)C(N3CCN(CC4=CC=CC5=C4CN(C(C[C@H]6C(N[C@H](C(N7[C@H](C#N)CC(F)(F)C7)=O)C6)=O)=O)C5)CC3)=O)CN8CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC8
Molecular Formula
C65H84F2IN13O13
Molecular Weight
1420.34
References & Citations
[1]Lindeman SD, et al. FAP Radioligand Linker Optimization Improves Tumor Dose and Tumor-to-Healthy Organ Ratios in 4T1 Syngeneic Model. J Med Chem. 2024 Jul 25;67 (14) :11827-11840.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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ARC0416KU-19-19
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138560-AF-BiotinKeratin 19 (K19, Keratin-19, CK-19, Cytokeratin-19) (Biotin)
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138560-AF-PEKeratin 19 (K19, Keratin-19, CK-19, Cytokeratin-19) (PE)
138560-AF-HRPKeratin 19 (K19, Keratin-19, CK-19, Cytokeratin-19) (HRP)
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