KM-001-E2

• Description:

  (S) -KM-001 ((S) -KM-001) is the enantiomer of KM-001 (HY-153275) . KM-001 is a TRPV3 channel antagonist and can be used for studying skin itching and keratinosis diseases[1].

• Product Name Alternative:

  (S) -KM-001

• UNSPSC:

  12352005

• Target:

  Drug Isomer

• Related Pathways:

  Others

• Field of Research:

  Others

• Purity:

  99.08

• Smiles:

  OCC1=C([C@H]2CN(CC2)C(C3=CC=C(C=N3)F)=O)C=CC(C4=C(C5CC5)C=CC=C4)=C1

• Molecular Formula:

  C26H25FN2O2

• Molecular Weight:

  416.49

• References & Citations:

  [1]Barak SL, et al. 629 Evaluating the safety and efficacy of topical KM-001, a TRPV3 inhibitor, for treatment of pruritus in patients with Lichen Simplex Chronicus (LSC) : a first in human, double-blind, randomized vehicle-controlled study. Journal of Investigative Dermatology. 2023 May 1;143 (5) :S108.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2682864-43-1]