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GLX481372

CAT: 0804-HY-148936Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-148936Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GLX481372 is a NADPH Oxidase (NOX) inhibitor. GLX481372 potently inhibits NOX4/5 activities with IC50 values of 0.68 and 0.57 μM. GLX481372 also has weak inhibitory activity against NOX1, NOX2, and NOX3, with IC50 values of 7, 16 and 3.2 μM respectively. GLX481372 can inhibit ROS production. GLX481372 can be used for the researches of inflammation, cardiovascular and metabolic disease, such as diabetes[1].
CAS Number
1990478-58-4
UNSPSC
12352005
Target
NADPH Oxidase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Smiles
CC1=CC(NC2=NC(N)=NC(CN3CCN(CC3)C4=CC=C(C)C=C4)=N2)=CC=C1C
Molecular Formula
C23H29N7
Molecular Weight
403.52
References & Citations
[1]Chocry M, et al. The NADPH Oxidase Family and Its Inhibitors. Antioxid Redox Signal. 2020 Aug 10;33 (5) :332-353.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOX1; NOX2; NOX4; NOX5

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