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PNU-183792

CAT: 0804-HY-148852-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148852-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC50 values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV) [1].
CAS Number
282536-25-8
UNSPSC
12352005
Target
HSV
Related Pathways
Anti-infection
Field of Research
Infection
Purity
98.88
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(C)C2=CC=C(CN3CCOCC3)C=C2C1=O)NCC4=CC=C(C=C4)Cl
Molecular Formula
C23H24ClN3O3
Molecular Weight
425.91
References & Citations
[1]Brideau RJ, et al. Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses. Antiviral Res. 2002 Apr;54 (1) :19-28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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