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Tecarfarin-13C, d3

CAT: 0804-HY-14854SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14854SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tecarfarin-13C, d3 (ATI-5923-13C, d3) is 13C labeled Tecarfarin. Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X[1]. Tecarfarin has the antithrombotic activity [2].
Product Name Alternative
ATI-5923-13C, d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds; VKOR
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=CC=C(CC2=C(O)C3=C(C=CC=C3)OC2=O)C=C1)OC(C(F)(F)F)(C(F)(F)F)[13C]([2H])([2H])[2H]
Molecular Formula
C20 13CH11D3F6O5
Molecular Weight
464.33
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hobl EL, et al. Tecarfarin: A Novel Vitamin K Antagonist. Thromb Haemost. 2017 Nov;117 (11) :2009-2011.|[3]Bowersox SS, et al. Antithrombotic activity of the novel oral anticoagulant, Tecarfarin [Sodium 3-[4- ((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in animal models. Thromb Res. 2010 Nov;126 (5) :e383-8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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