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Riociguat-d3

CAT: 0804-HY-14779S3Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14779S3Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Riociguat-d3 (BAY 632521-d3) is deuterium labeled Riociguat. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
CAS Number
1304478-72-5
Product Name Alternative
BAY 632521-d3
UNSPSC
12352005
Target
Guanylate Cyclase; Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
NC1=NC(C(C2=CC=CN=C23)=NN3CC4=C(C=CC=C4)F)=NC(N)=C1N(C([2H])([2H])[2H])C(OC)=O
Molecular Formula
C20H16D3FN8O2
Molecular Weight
425.43
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Schermuly RT, et al. Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension. Eur Respir J. 2008 Oct;32 (4) :881-91.|[3]Schermuly RT, et al. Riociguat for the treatment of pulmonary hypertension. Expert Opin Investig Drugs. 2011 Apr;20 (4) :567-76.|[4]Donda K, et al. Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth. PLoS One. 2018 Jul 10;13 (7) :e0199927.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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