BI-9466

• Description:

  BI-9466 (Compound 2) is a nuclear receptor-binding SET domain 3 (NSD3) -PWWP1 domain antagonist with a Kd of 144 µM. BI-9466 is a negative control compound of BI-9321 (HY-114208) . BI-9466 has no inhibitory activity against NSD3-PWWP1 domain by introduction of a much basic nitrogen heterocycle at the 5-position of BI-9321[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Smiles:

  CN1C=NC(C2=C(C)C=C(CN)C=C2C)=C1C3=CN=CN3C

• Molecular Formula:

  C17H21N5

• Molecular Weight:

  295.38

• References & Citations:

  [1]Böttcher J, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol. 2019 Aug;15 (8) :822-829.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2538293-52-4]