Deruxtecan (GMP)

• Description:

  Deruxtecan (GMP) (MC-GGFG-DXD (GMP) ) is Deruxtecan (HY-13631E) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813) [1][2].

• Product Name Alternative:

  MC-GGFG-DXD (GMP)

• UNSPSC:

  12352005

• Hazard Statement:

  H303, H333

• Target:

  Drug-Linker Conjugates for ADC

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Field of Research:

  Cancer

• Smiles:

  O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C48)=O)=O)=O)=O)=O)=O

• Molecular Formula:

  C52H56FN9O13

• Molecular Weight:

  1034.05

• Precautions:

  H303, H333

• References & Citations:

  [1]NOGUCHI, Shigeru, et al. METHOD FOR SELECTIVELY MANUFACTURING ANTIBODY-DRUG CONJUGATE. WO2017002776A1.|[2]Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107 (7) :1039-46.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Store in a tightly closed, dry and light-resistant container below -15°C

• Scientific Category:

  GMP Small Molecules

• Clinical Information:

  No Development Reported

• CAS Number:

  [1599440-13-7]