2',5'-Dideoxyadenosine

CAT: 0804-HY-135878-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-135878-01Size:5 mg
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Description
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].
CAS Number
[6698-26-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adenylate Cyclase; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-5-dideoxyadenosine.html
Purity
99.86
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C[C@@H]1[C@H](C[C@H](N2C=NC3=C(N=CN=C32)N)O1)O
Molecular Formula
C10H13N5O2
Molecular Weight
235.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38 (6) :848-53.|[2]Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25 (3) :331-8.|[3]Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33 (5) :6622-6631.|[4]Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae) . J Ethnopharmacol. 2013 Oct 28;150 (1) :154-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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