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RWJ-60475

CAT: 0804-HY-135477Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135477Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RWJ-60475 is a cell-permeable tyrosine phosphatase inhibitor with an IC50 of 3.3 μM. RWJ-60475, by inhibiting the activity of CD45/CD148 phosphatase, interferes with the phagocytic function of macrophages, thereby blocking the invasion of Legionella pneumophila into host cells and the transport of effector proteins. RWJ-60475 significantly reduces the uptake of bacterial particles by macrophages. RWJ-60475 can be used in the research of anti-infection targeting host factors[1][2].
CAS Number
204130-08-5
UNSPSC
12352005
Target
Bacterial; Phosphatase
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
OP(O)(C(C1=CC([N+]([O-])=O)=CC=C1OC2=CC=C(Br)C=C2)O)=O
Molecular Formula
C13H11BrNO7P
Molecular Weight
404.11
References & Citations
[1]Charpentier X, et al. Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS pathogens. 2009 Jul 3;5 (7) :e1000501.|[2]Karvinen J, et al. Fluorescence quenching-based assays for hydrolyzing enzymes. Application of time-resolved fluorometry in assays for caspase, helicase, and phosphatase. Anal Chem. 2004 Mar 1;76 (5) :1429-36.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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