RWJ-49815

CAT: 0804-HY-123779Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-123779Size:1 Each
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Description
RWJ-49815 is a histidine kinase inhibitor (IC50 = 1.6 uM) . RWJ-49815 inhibits the autophosphorylation of kinase A in the KinA-Spo0F two-component signal transduction system in vitro. RWJ-49815 inhibits the growth of bacteria such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. RWJ-49815 also inhibits the growth of Fungal such as Saccharomyces cerevisiae and Candida albicans[1][2].
CAS Number
[193282-45-0]
UNSPSC
12352005
Target
Bacterial; Fungal
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
NC(NCCC1=CC=C(OCCC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)=N
Molecular Formula
C30H31N3O
Molecular Weight
449.59
References & Citations
[1]Barrett JF, et al. Antibacterial agents that inhibit two-component signal transduction systems. Proc Natl Acad Sci U S A. 1998 Apr 28;95 (9) :5317-22.|[2]Deschenes RJ, et al. Antifungal properties and target evaluation of three putative bacterial histidine kinase inhibitors. Antimicrob Agents Chemother. 1999 Jul;43 (7) :1700-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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