RWJ-49815

• Description :

  RWJ-49815 is a histidine kinase inhibitor (IC50 = 1.6 uM) . RWJ-49815 inhibits the autophosphorylation of kinase A in the KinA-Spo0F two-component signal transduction system in vitro. RWJ-49815 inhibits the growth of bacteria such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. RWJ-49815 also inhibits the growth of Fungal such as Saccharomyces cerevisiae and Candida albicans[1][2].

• CAS Number :

  [193282-45-0]

• UNSPSC :

  12352005

• Target :

  Bacterial; Fungal

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Smiles :

  NC(NCCC1=CC=C(OCCC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)=N

• Molecular Formula :

  C30H31N3O

• Molecular Weight :

  449.59

• References & Citations :

  [1]Barrett JF, et al. Antibacterial agents that inhibit two-component signal transduction systems. Proc Natl Acad Sci U S A. 1998 Apr 28;95 (9) :5317-22.|[2]Deschenes RJ, et al. Antifungal properties and target evaluation of three putative bacterial histidine kinase inhibitors. Antimicrob Agents Chemother. 1999 Jul;43 (7) :1700-3.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported