4-Desmethoxy Omeprazole-d3

CAT: 0804-HY-135111S-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-135111S-01Size:1 mg

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Description

4-Desmethoxy Omeprazole-d3 is the deuterium labeled 4-Desmethoxy Omeprazole. 4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Kiof 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].

CAS Number

1794759-05-9

UNSPSC

12352005

Target

Drug Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Metabolic Disease

Solubility

10 mM in DMSO

Smiles

CC(C=C(C=N1)C)=C1CS(C2=NC3=CC(OC([2H])([2H])[2H])=CC=C3N2)=O

Molecular Formula

C16H14D3N3O2S

Molecular Weight

318.41

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32 (8) :821-7.|[3]Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37 (1) :145-50.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

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