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Urolithin D (Standard)

CAT: 0804-HY-133178RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-133178RSize:1 Each
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Description
Urolithin D (Standard) (3,4,8,9-Tetrahydroxy urolithin (Standard) ) is the analytical standard of Urolithin D. This product is intended for research and analytical applications. Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC50 of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases[1].
CAS Number
131086-98-1
Product Name Alternative
3,4,8,9-Tetrahydroxy urolithin (Standard)
UNSPSC
12352005
Target
AMPK; Ephrin Receptor; PPAR; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Smiles
O=C1C2=CC(O)=C(O)C=C2C3=CC=C(O)C(O)=C3O1
Molecular Formula
C13H8O6
Molecular Weight
260.20
References & Citations
[1]Giorgio C, et al. The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells. Mol Nutr Food Res. 2015 Nov;59 (11) :2155-67.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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